A mediation analysis to explain socio-economic differences in bladder cancer survival.

ABSTRACT:

Introduction

This study aims to disentangle heterogeneity in the survival of bladder cancer (BC) patients of different socioeconomic status (SES) by identifying potential mediators of the relationship.

Methods

The Bladder Cancer Database Sweden (BladderBaSe) was used to select patients diagnosed between 1997 and 2014 with Tis/Ta-T4 disease. The education level was used as a proxy for SES. Accelerated failure time models were used to investigate the association between SES and survival. Mediation analysis was used to investigate potential mediators of the association also accounting for interaction.

Results

The study included 37 755 patients from the BladderBaSe. Patients diagnosed with both non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer

SUBMITTER: Russell B 

PROVIDER: S-EPMC7571835 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature