Identification of a novel prognostic DNA methylation signature for lung adenocarcinoma based on consensus clustering method.

ABSTRACT: Abnormal DNA methylation persists throughout carcinogenesis and cancer development. Hence, gene promoter methylation may act as a prognostic tool and provide new potential therapeutic targets for patients with lung adenocarcinoma (LUAD). In this study, to explore prognostic methylation signature, data regarding DNA methylation and RNA-seq, and clinical data of patients with LUAD from the Cancer Genome Atlas database (TCGA) were downloaded. After data preprocessing, the methylation data were divided into training (N = 405) and test sets (N = 62). Then, patients in the training set were assigned to five subgroups based on their different methylation levels using the consensus clustering method. We comprehensively analyzed the survival information, methylation levels, and clinical variables,

SUBMITTER: Cai Q 

PROVIDER: S-EPMC7571836 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature