Meta-regression analysis of the efficacy of alendronate for prevention of glucocorticoid-induced fractures.

ABSTRACT:

Background

What affects the efficacy of alendronate for prevention of glucocorticoid-induced (GI) fractures remains unclear. We aimed to explore the factors affecting alendronate's efficacy, and further identify subgroup effects of alendronate in preventing GI fractures.

Methods

We searched 3 databases. Random-effects meta-analysis was conducted to synthesize risk ratio (RR) and 95% confidence interval (CI) for each endpoint. Meta-regression analysis was used to explore sources of heterogeneity, and subgroup analysis was used to address heterogeneity and evaluate subgroup effects. We detected publication bias using funnel plots and Egger tests.

Results

We included 13 papers from 12 unique studies involving 46431 participants. Glucocorticoid (GC) dosage (P = .053) and

SUBMITTER: Qiu M 

PROVIDER: S-EPMC7571885 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature