Topiramate-related adverse events: Pattern and signals in the Korea Adverse Event Reporting System, 2010-2017.

ABSTRACT: Despite safety concerns associated with topiramate use, the pattern of adverse events and signal analysis of antiepileptic drugs remain elusive.We aimed to determine patient demographics and characteristics of reported AEs of topiramate and to detect the associated signals by comparing those of other antiepileptics.We used the Korea Institute of Drug Safety & Risk Management-Korea Adverse Event Reporting System Database (KIDS-KD) from 2010 to 2017 to determine patient demographics and characteristics of reported AEs for topiramate and other antiepileptics. The proportional reporting ratio, reporting odds ratio, and information component were used in signal detection. Signals were compared against drug labels in Korea, the UK, the EU, and the US.A total of 1300 adverse events cases of topir

SUBMITTER: Choi J 

PROVIDER: S-EPMC7571929 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature