Association of ANRIL polymorphisms with coronary artery disease: A systemic meta-analysis.

ABSTRACT:

Background

The long noncoding RNAs have gradually been reported to be an important class of RNAs with pivotal roles in the development and progression of myocardial infarction (MI). In this study, we hypothesized that genetic variant of cyclin-dependent kinase inhibitor 2B antisense RNA (ANRIL) may affect the prognosis of MI patients.

Methods

A systematic review and meta-analysis of studies including 11,269 cases and 10,707 controls on the association of 5 ANRIL single nucleotide polymorphism and the overall risk of MI or coronary artery disease (CAD) was performed.

Results

In the meta-analysis, rs4977574 A > G, rs1333040 C > T, rs1333042 A > G and rs10757274 A > G ANRIL polymorphisms were correlated with overall MI or CAD risk. No significant associations were found

SUBMITTER: Zhang YN 

PROVIDER: S-EPMC7571950 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature