Poor effect of osimertinib on EGFR exon 20 insertion-positive lung adenocarcinoma: A case report.

ABSTRACT:

Introduction

The clinical efficacy of osimertinib for patients with lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) exon 20 insertion mutations is unclear. Few case reports exist on the successful treatment of such tumors with osimertinib. We report a case wherein osimertinib administration had no effect in a patient with EGFR exon 20 insertion-positive lung adenocarcinoma.

Patient concerns

A 48-year-old never-smoking woman was referred to our hospital for chronic cough. Computed tomography (CT) and positron emission tomography-CT revealed a nodule in the right middle lobe, consolidation in the right upper lobe, multiple lymph node metastases, liver metastasis, and multiple bone metastases.

Diagnosis

On the basis of further examination using tran

SUBMITTER: Inagaki Y 

PROVIDER: S-EPMC7572000 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature