External Validation of International Risk-Prediction Models of IgA Nephropathy in an Asian-Caucasian Cohort.

ABSTRACT:

Introduction

Two prediction models for IgA nephropathy (IgAN) using clinical variables and the Oxford MEST scores were developed and validated in 2 multiethnic cohorts. Additional external validation is required.

Methods

Biopsy-proven Chinese and Argentinian patients with IgAN were included. The primary outcome was defined as a 50% decline in estimated glomerular filtration rate (eGFR) or end-stage renal disease. C-statistics and stratified analyses were used for model discrimination, coefficient of determination (R² _D) for model fit, and calibration plots for model calibration. Baseline survival function was also evaluated.

Results

A total of 1275 patients were enrolled, with a mean age of 34 (interquartile range: 27-42) years, 50% of whom (638

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7572322 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature