Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism.

ABSTRACT: Pharmacological ascorbate (P-AscH^-, high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer (PDAC) utilizing P-AscH^- have demonstrated increases in progression free survival, suggesting a reduction in metastatic disease burden. The purpose of this study was to determine the effects of P-AscH^- on metastatic PDAC. Several in vitro and in vivo mechanisms involved in PDAC metastases were investigated following treatment with P-AscH^-. Serum from PDAC patients in clinical trials with P-AscH^- were tested for the presence and quantity of circulating tumor cell-derived nucleases. P-AscH^- inhibited invasion, basement membrane degradation, decreased matrix metall

SUBMITTER: O'Leary BR 

PROVIDER: S-EPMC7572461 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature