Early and sustained improvement in fatigue-related quality of life following red blood cell transfusion in outpatients.

ABSTRACT:

Purpose

Outpatients with hematologic disease often receive red cell transfusion to treat anemia and fatigue. The effect of transfusion on fatigue-related quality of life and how well this effect is sustained has not been quantified. The study aim was to describe the early and sustained impact over 4 weeks of red cells on patient-reported fatigue in outpatients age ≥ 50 receiving transfusion as routine clinical care.

Methods

FACIT-Fatigue scale scores were measured pre-transfusion and at visits targeting 3, 7, and 28 days post-transfusion. Group-based trajectory modeling of patient fatigue scores by study day was used to identify the number of distinct trajectories (Groups), then longitudinal mixed effects modeling of fatigue scores was used to estimate group-specific mean im

SUBMITTER: Bruhn R 

PROVIDER: S-EPMC7572478 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature