Inflammation and depression treatment response to electroconvulsive therapy: Sex-specific role of interleukin-8.

ABSTRACT: Females suffer from depression at twice the rate of males and have differential neural and emotional responses to inflammation. However, sex-specific evaluation of relationships between inflammation and response to depression treatments are lacking. Some data suggest that interleukin(IL)-8 predicts treatment response to antidepressants and has a relationship with depressive symptom severity. This study examines whether IL-8 predicts treatment response to electroconvulsive therapy (ECT), and whether there are sex specific effects. In 40 depressed patients (22 female), plasma levels of IL-8, as well as other markers of inflammation including IL-6, IL-10, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were obtained prior to administration of ECT and after completion of the index

SUBMITTER: Kruse JL 

PROVIDER: S-EPMC7572496 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature