Nonsteroidal Anti-inflammatory Use and LRRK2 Parkinson's Disease Penetrance.

ABSTRACT:

Background

The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is incomplete and may be influenced by environmental and/or other genetic factors. Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to reduce inflammation and may lower Parkinson's disease (PD) risk, but their role in LRRK2-associated PD is unknown.

Objectives

The objective of this study is to evaluate the association of regular NSAID use and LRRK2-associated PD.

Methods

Symptomatic ("LRRK2-PD") and asymptomatic ("LRRK2-non-PD") participants with LRRK2 G2019S, R1441X, or I2020T variants (definitely pathogenic variant carriers) or G2385R or R1628P variants (risk variant carriers) from 2 international cohorts provided information on regular ibuprofen and/or aspirin use (≥2 pills/week for

SUBMITTER: San Luciano M 

PROVIDER: S-EPMC7572560 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature