Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.

ABSTRACT: Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although research on brain metastasis was considered a minor aspect in the past due to its untreatable nature and invariable lethality, nowadays, limited but encouraging examples have questioned this statement, making it more attractive for basic and clinical researchers. Evidences of its own biological identity (i.e., specific microenvironment) and particular therapeutic requirements (i.e., presence of blood-brain barrier, blood-tumor barrier, molecular differences with the primary tumor) are thought to be critical aspects that must be functionally exploited using preclinical models. We present the coordinated effort of

SUBMITTER: Valiente M 

PROVIDER: S-EPMC7572582 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature