Medication adherence and rate of nicotine metabolism are associated with response to treatment with varenicline among smokers with HIV.

ABSTRACT:

Introduction

PLWHA who smoke have shown lower cessation rates within placebo-controlled randomized trials of varenicline. Adherence and rate of nicotine metabolism may be associated with quit rates in such clinical trials.

Methods

This secondary analysis of a randomized placebo-controlled trial of varenicline for smoking among PLWHA (N = 179) examined the relationship between varenicline adherence (pill count, ≥80% of pills), nicotine metabolism (based on the nicotine metabolite ratio; NMR) and end-of-treatment smoking cessation (self-reported 7-day point prevalence abstinence, confirmed with carbon monoxide of ≤ 8 ppm, at the end of treatment; EOT).

Results

Combining varenicline and placebo arms, greater adherence (OR = 1.011, 95% CI:1.00-1.02, p = 0.051) and faster

SUBMITTER: Bauer AM 

PROVIDER: S-EPMC7572610 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature