Intranasal ketamine for acute pain management in children: A systematic review and meta-analysis.

ABSTRACT:

Study objective

To assess the efficacy and safety of intranasal analgesic-dose ketamine as compared to intranasal fentanyl for pediatric acute pain.

Methods

A systematic review and meta-analysis was performed following the PRISMA guidelines. We searched PubMed, Embase, and Scopus databases for randomized controlled trials from inception to December 2019. We conducted meta-analysis with random-effects models to evaluate pain reduction, rescue analgesia, adverse events and sedation between intranasal ketamine and intranasal fentanyl. Random-effects models were used to estimate weighted mean differences (WMD) and pooled relative risks (RR).

Results

A total of 546 studies were screened and 4 trials were included. In the meta-analysis of 4 studies including 276 patients, k

SUBMITTER: Oliveira J E Silva L 

PROVIDER: S-EPMC7572639 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature