Protons and High-Linear Energy Transfer Radiation Induce Genetically Similar Lymphomas With High Penetrance in a Mouse Model of the Aging Human Hematopoietic System.

ABSTRACT:

Purpose

Humans are exposed to charged particles in different scenarios. The use of protons and high-linear energy transfer (LET) in cancer treatment is steadily growing. In outer space, astronauts will be exposed to a mixed radiation field composed of both protons and heavy ions, in particularly the long-term space missions outside of earth's magnetosphere. Thus, understanding the radiobiology and transforming potential of these types of ionizing radiation are of paramount importance.

Methods and materials

We examined the effect of 10 or 100 cGy of whole-body doses of protons or ²⁸Si ions on the hematopoietic system of a genetic model of aging based on recent studies that showed selective loss of the MLH1 protein in human hematopoietic stems with age.

Results</

SUBMITTER: Patel R 

PROVIDER: S-EPMC7572653 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature