ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen.

ABSTRACT: Identification of tumor-specific cell surface antigens has proven challenging, as the vast majority of tumor-associated antigens are also expressed in normal tissues. In mesothelioma, we identified a highly specific tumor cell surface antigen that can be targeted for therapy development. Mesothelioma is caused by malignant transformation of the mesothelium, is incurable, and can be categorized into three histologic subtypes: epithelioid, biphasic, and sarcomatoid. To identity novel mesothelioma cell surface antigens with broad subtype coverage and high tissue specificity, we have previously selected phage antibody display libraries on live mesothelioma cells and tissues following counterselection on normal cells and identified a panel of human antibodies that bind all subtypes of mesotheli

SUBMITTER: Su Y 

PROVIDER: S-EPMC7572689 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature