Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study.

ABSTRACT:

Background and aims

Fetal exposure to endocrine disruptors such as phthalates and bisphenols may lead to developmental metabolic adaptations. We examined associations of maternal phthalate and bisphenol urine concentrations during pregnancy with lipids, insulin, and glucose concentrations at school age.

Methods

In a population-based, prospective cohort study among 757 mother-child pairs, we measured maternal phthalate and bisphenol urine concentrations in first, second and third trimester of pregnancy. We measured non-fasting lipids, glucose and insulin blood concentrations of their children at a mean age of 9.7 (standard deviation 0.2) years. Analyses were performed for boys and girls separately.

Results

An interquartile range (IQR) higher natural log transformed thi

SUBMITTER: Sol CM 

PROVIDER: S-EPMC7572773 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature