PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex.

ABSTRACT: Postsynaptic Density Protein-95 (PSD-95) is a major scaffolding protein in the excitatory synapses in the brain and a critical regulator of synaptic maturation for NMDA and AMPA receptors. PSD-95 deficiency has been linked to cognitive and learning deficits implicated in neurodevelopmental disorders such as autism and schizophrenia. Previous studies have shown that PSD-95 deficiency causes a significant reduction in the excitatory response in the hippocampus. However, little is known about whether PSD-95 deficiency will affect gamma-aminobutyric acid (GABA)ergic inhibitory synapses. Using a PSD-95 transgenic mouse model (PSD-95^+/-), we studied how PSD-95 deficiency affects GABA_A receptor expression and function in the medial prefrontal cortex (mPFC) during adolescence

SUBMITTER: McEachern EP 

PROVIDER: S-EPMC7572776 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature