From BDNF to reading: Neural activation and phonological processing as multiple mediators.

ABSTRACT: The BDNF gene is a prominent promoter of neuronal development, maturation and plasticity. Its Val⁶⁶Met polymorphism affects brain morphology and function within several areas and is associated with several cognitive functions and neurodevelopmental disorder susceptibility. Recently, it has been associated with reading, reading-related traits and altered neural activation in reading-related brain regions. However, it remains unknown if the intermediate phenotypes (IPs, such as brain activation and phonological skills) mediate the pathway from gene to reading or reading disability. By conducting a serial multiple mediation model in a sample of 94 children (age 5-13), our findings revealed no direct effects of genotype on reading. Instead, we found that genotype is associated with

SUBMITTER: Mascheretti S 

PROVIDER: S-EPMC7572787 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature