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Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2.

ABSTRACT: With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2)_ infecting >16 million people worldwide as of 28 July 2020, causing >650 000 deaths, there is a desperate need for therapeutic agents and vaccines. Building on knowledge of previous outbreaks of SARS-CoV-1 and Middle East respiratory syndrome (MERS), the development of therapeutic antibodies and vaccines against coronavirus disease 2019 (COVID-19) is taking place at an unprecedented speed. Current efforts towards the development of neutralizing antibodies against COVID-19 are summarized. We also highlight the importance of a fruitful antibody development pipeline to combat the potential escape plans of SARS-CoV-2, including somatic mutations and antibody-dependent enhancement (ADE).

SUBMITTER: Renn A

PROVIDER: S-EPMC7572790 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2.

Renn Alex A Fu Ying Y Hu Xin X Hall Matthew D MD Simeonov Anton A

Trends in pharmacological sciences 20200731 11

With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2)_ infecting >16 million people worldwide as of 28 July 2020, causing >650 000 deaths, there is a desperate need for therapeutic agents and vaccines. Building on knowledge of previous outbreaks of SARS-CoV-1 and Middle East respiratory syndrome (MERS), the development of therapeutic antibodies and vaccines against coronavirus disease 2019 (COVID-19) is taking place at an unprecedented speed. Current efforts toward ...[more]

PMID: 32829936

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