Sex differences in cardiovascular actions of the renin-angiotensin system.

ABSTRACT: Cardiovascular disease (CVD) remains a worldwide public health concern despite decades of research and the availability of numerous targeted therapies. While the intrinsic physiological mechanisms regulating cardiovascular function are similar between males and females, marked sex differences have been established in terms of CVD onset, pathophysiology, manifestation, susceptibility, prevalence, treatment responses and outcomes in animal models and clinical populations. Premenopausal females are generally protected from CVD in comparison to men of similar age, with females tending to develop cardiovascular complications later in life following menopause. Emerging evidence suggests this cardioprotection in females is, in part, attributed to sex differences in hormonal regulators, such as th

SUBMITTER: Medina D 

PROVIDER: S-EPMC7572792 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature