Effect of exogenous progesterone administration on smoking topography.

ABSTRACT:

Introduction

Progesterone has been implicated as protective against drug taking behaviors, including combustible cigarettes. While prior research indicates higher endogenous progesterone levels are associated with a reduction in smoking intensity (as measured by smoking topography), it is unknown if exogenous delivery of progesterone may have the same effect.

Methods

This double-blind, counterbalanced, cross-over randomized trial enrolled women between the ages of 18 and 40 who smoked at least five cigarettes per day and were currently using oral contraceptives. After overnight abstinence participants attended two topography lab sessions. One lab session was conducted during progesterone (200 mg twice per day) treatment and the other was during placebo treatment. Analyses in

SUBMITTER: Allen A 

PROVIDER: S-EPMC7572886 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature