Aspergillus-Derived Galactosaminogalactan Triggers Complement Activation on Human Platelets.

ABSTRACT: Invasive fungal infections caused by Aspergillus (A.) and Mucorales species still represent life-threatening diseases in immunocompromised individuals, and deeper knowledge about fungal interactions with elements of innate immunity, such as complement and platelets, appears essential for optimized therapy. Previous studies showed that galactosaminogalactan secreted by A. fumigatus and A. flavus is deposited on platelets, thereby inducing their activation. Since the altered platelet surface is a putative trigger for complement activation, we aimed to study the interplay of platelets with complement in the presence of fungal GAG. Culture supernatants (SN) of A. fumigatus and A. flavus both induced not only GAG deposition but also subsequent depositio

SUBMITTER: Deshmukh H 

PROVIDER: S-EPMC7573070 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature