Lung Cancer Screening with Low-Dose CT: a Meta-Analysis.

ABSTRACT:

Background

Randomized controlled trials have evaluated the efficacy of low-dose CT (LDCT) lung cancer screening on lung cancer (LC) outcomes.

Objective

Meta-analyze LDCT lung cancer screening trials.

Methods

We identified studies by searching PubMed, Google Scholar, the Cochrane Registry, ClinicalTrials.gov , and reference lists from retrieved publications. We abstracted data on study design features, stage I LC diagnoses, LC and overall mortality, false positive results, harm from invasive diagnostic procedures, overdiagnosis, and significant incidental findings. We assessed study quality using the Cochrane risk-of-bias tool. We used random-effects models to calculate relative risks and assessed effect modulators with subgroup analyses and meta-regression.

Results

SUBMITTER: Hoffman RM 

PROVIDER: S-EPMC7573097 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature