Selective Stimulation of Duplicated Atlantic Salmon MHC Pathway Genes by Interferon-Gamma.

ABSTRACT: Induction of cellular immune responses rely on Major histocompatibility complex (MHC) molecules presenting pathogenic peptides to T cells. Peptide processing, transport, loading and editing is a constitutive process in most cell types, but is accelerated upon infection. Recently, an unexpected complexity in the number of functional genes involved in MHC class I peptide cleavage, peptide transport, peptide loading and editing was found in teleosts, originating from the second and third whole genome duplication events. Salmonids have expanded upon this with functional duplicates also from a fourth unique salmonid whole genome duplication. However, little is known about how individual gene duplicates respond in the context of stimulation. Here we set out to investigate how interferon gamma (I

SUBMITTER: Grimholt U 

PROVIDER: S-EPMC7573153 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature