Novel Porcine Retina Cultivation Techniques Provide Improved Photoreceptor Preservation.

ABSTRACT: Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries among people over 60 years. It has multiple triggers and risk factors, but despite intense research efforts, its pathomechanisms are currently not completely understood. AMD pathogenesis is characterized by soft drusen in Bruch's membrane and involves the retinal pigment epithelium-Bruch's membrane-choroid complex and adjacent structures, like photoreceptors. This study explores the potential of novel cultivation techniques to preserve photoreceptors in retinal explants to gain better insights in AMD pathology. The porcine retina explants were cultured for 4 and 8 days using three different explantation techniques, namely, control (photoreceptors facing down, touching the filter), filter (p

SUBMITTER: Wagner N 

PROVIDER: S-EPMC7573241 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature