AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals.

ABSTRACT: Motile cilia are hairlike structures that line the respiratory and reproductive tracts and the middle ear and generate fluid flow in these organs via synchronized beating. Cilium growth is a highly regulated process that is assumed to be important for flow generation. Recently, Kif19a, a kinesin residing at the cilia tip, was identified to be essential for ciliary length control through its microtubule depolymerization function. However, there is a lack of information on the nature of proteins and the integrated signaling mechanism regulating growth of motile cilia. Here, we report that adenylate cyclase 6 (AC6), a highly abundant AC isoform in airway epithelial cells, inhibits degradation of Kif19a by inhibiting autophagy, a cellular recycling mechanism for damaged proteins and organelles

SUBMITTER: Arora K 

PROVIDER: S-EPMC7573275 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature