The binding mechanism of the virulence factor Streptococcus suis adhesin P subtype to globotetraosylceramide is associated with systemic disease.

ABSTRACT: Streptococcus suis is part of the pig commensal microbiome but strains can also be pathogenic, causing pneumonia and meningitis in pigs as well as zoonotic meningitis. According to genomic analysis, S. suis is divided into asymptomatic carriage, respiratory and systemic strains with distinct genomic signatures. Because the strategies to target pathogenic S. suis are limited, new therapeutic approaches are needed. The virulence factor S. suis adhesin P (SadP) recognizes the galabiose Galα1-4Gal-oligosaccharide. Based on its oligosaccharide fine specificity, SadP can be divided into subtypes P_N and P_O We show here that subtype P_N is distributed in the systemic strains causing meningitis, whereas type P_O is found in asymp

SUBMITTER: Madar Johansson M 

PROVIDER: S-EPMC7573278 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature