Dynamic Alterations of Amplitude of Low-Frequency Fluctuations in Patients With Drug-Naive First-Episode Early Onset Schizophrenia.

ABSTRACT: Abnormalities in static neural activity have been widely reported in early onset schizophrenia (EOS). However, dynamic brain activity alterations over time in EOS are unclear. Here, we investigated whether temporal dynamic changes in spontaneous neural activity are influenced by EOS. A total of 78 drug-naïve first-episode patients with EOS and 90 healthy controls (HCs) were enrolled in this study. Dynamic amplitude of low-frequency fluctuations (dALFF) was performed to examine the abnormal time-varying local neural activity in EOS. Furthermore, we investigated the relationships between abnormalities in dALFF variability and clinical characteristics in EOS patients. Compared to HCs, EOS patients showed significantly decreased dALFF variability in the bilateral precuneus, right superior marg

SUBMITTER: Li Q 

PROVIDER: S-EPMC7573348 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature