Association of Multidrug Resistance Gene-1 (MDR1 C1236T) Polymorphism with the Risk of Acute Myeloid Leukemia in a Moroccan Population.

ABSTRACT: The human multidrug resistance MDR1 gene plays a crucial role in the absorption, transport, metabolism and elimination of harmful compounds. An impaired metabolism of these compounds related to genetic polymorphism may cause cancer such as acute myeloid leukemia AML.

Objective

The present study investigated the relationship between C1236T polymorphism and the risk of AML development in a sample of Moroccan population.

Methods

The present case-control study included 131 AML patients and 136 healthy controls. The MDR1 C1236T polymorphism was identified by PCR-RFLP method. Meta-analysis was performed to discuss our results. Statistical analyses were performed using SPSS, MetaGenyo and MedCalc.

Results

A positive association was found between the 1236TT mutant genotype and

SUBMITTER: Ait Boujmia OK 

PROVIDER: S-EPMC7573417 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature