Docosahexaenoic Acid Modulates NK Cell Effects on Neutrophils and Their Crosstalk.

ABSTRACT: Natural killer (NK) cells and neutrophils engage in crosstalk that is important in inflammation and likely also for resolution of inflammation. NK cells activate neutrophils and induce their infiltration to the inflamed sites but may also influence their apoptosis and their subsequent efferocytosis by macrophages. Several studies indicate that docosahexaenoic acid (DHA) can inhibit NK cell cytotoxicity but the effects of DHA on the ability of NK cells to engage in crosstalk with neutrophils and affect their functions have not been described. This study explored the kinetics of the effects of NK cells and NK cells pre-treated with DHA on neutrophil surface molecule expression and apoptosis, as well as the ability of NK cells to affect other neutrophil functions. In addition, the study explo

SUBMITTER: Jensen KN 

PROVIDER: S-EPMC7573488 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature