Imbalance of Circulating Tfh/Tfr Cells in Patients With Parkinson's Disease.

ABSTRACT: Background: Follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are essential for B cell differentiation, germinal center formation, and humoral immune responses. Immunity and inflammation have been thought to be involved in Parkinson's disease (PD). In this study, we aimed to identify whether circulating Tfh and Tfr (cTfh and cTfr) cells contribute to PD. Methods: Thirty-nine PD patients and 26 health controls (HCs) were enrolled. The numbers of cTfh (CD4⁺CXCR5⁺PD-1⁺) cells and cTfr (CD4⁺CXCR5⁺CD25^hiCD127^low) cells were analyzed via flow cytometry. The serum concentrations of interleukin (IL)-4, IL-10, IL-21, and transforming growth factor (TGF)-β were examined by cytometric bead

SUBMITTER: Zhao X 

PROVIDER: S-EPMC7573556 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature