The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors.

ABSTRACT: Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and interpreting chemical cues in the environment. We reasoned that the liver, the largest metabolic organ in the body, is primed to take advantage of some of these sensory receptors in order to sense and regulate blood content and metabolism. In this study, we report the expression of novel hepatic sensory receptors - including 7 ORs, 6 bitter TRs, and 1 Opn - identified through a systematic molecular biology screening approach. We further determined that several of these receptors ar

SUBMITTER: Kurtz R 

PROVIDER: S-EPMC7573564 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature