Translating Preclinical Research for Exercise Oncology: Take It to the VO_2max.

ABSTRACT: Several observational studies have found that the risk for breast cancer is significantly reduced in persons who engage in greater amounts of physical activity. Additional observational studies of breast cancer survivors indicate that greater physical activity before or after diagnosis associates with reduced disease-specific mortality. However, no large randomized controlled trials have examined the effect of structured exercise training on disease outcomes in breast cancer. Among the many hurdles in designing such trials lies the challenge of determining how a given regimen of exercise from efficacious preclinical studies can be extrapolated to an equivalent "dose" in humans to guide decisions around treatment regimen in early-phase studies. We argue that preclinical researchers in exerc

SUBMITTER: Lamkin DM 

PROVIDER: S-EPMC7573565 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature