Development of synthetic lethality in cancer: molecular and cellular classification.

ABSTRACT: Recently, genetically targeted cancer therapies have been a topic of great interest. Synthetic lethality provides a new approach for the treatment of mutated genes that were previously considered unable to be targeted in traditional genotype-targeted treatments. The increasing researches and applications in the clinical setting made synthetic lethality a promising anticancer treatment option. However, the current understandings on different conditions of synthetic lethality have not been systematically assessed and the application of synthetic lethality in clinical practice still faces many challenges. Here, we propose a novel and systematic classification of synthetic lethality divided into gene level, pathway level, organelle level, and conditional synthetic lethality, according to the d

SUBMITTER: Li S 

PROVIDER: S-EPMC7573576 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature