Effects of Platycodin D on apoptosis, migration, invasion and cell cycle arrest of gallbladder cancer cells.

ABSTRACT: Platycodin D (PD) is a triterpenoid saponin that exists in the roots of Platycodonis. It exhibits evident growth inhibitory effects and potent cytotoxicity against multiple types of cancer. Gallbladder cancer (GBC) is the most common malignant disease of the biliary tract system. Patients with GBC usually have limited available treatment strategies and a poor prognosis. The present study investigated the antitumor effects of PD on human GBC cells in vitro and its underlying molecular mechanisms of action. The results indicated that PD, as assessed using MTT and colony forming assays, induced evident growth inhibition. Flow cytometry indicated that PD robustly induced apoptosis and blocked GBC cells at the G₂/M phase. Cell migration and invasion assays demonstrated that PD

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7573877 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature