Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells.

ABSTRACT: Mitochondria serve a vital role in cellular homeostasis as they regulate cell proliferation and death pathways, which are attributed to mitochondrial bioenergetics, free radicals and metabolism. Alterations in mitochondrial functions have been reported in various diseases, including cancer. Colorectal cancer (CRC) is one of the most common metastatic cancer types with high mortality rates. Although mitochondrial oxidative stress has been associated with CRC, its specific mechanism and contribution to metastatic progression remain poorly understood. Therefore, the aims of the present study were to investigate the role of mitochondria in CRC cells with low and high metastatic potential and to evaluate the contribution of mitochondrial respiratory chain (RC) complexes in oncogenic signaling p

SUBMITTER: Rai NK 

PROVIDER: S-EPMC7573887 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature