Predicted functional interactome of Caenorhabditis elegans and a web tool for the functional interpretation of differentially expressed genes.

ABSTRACT:

Background

The nematode worm, Caenorhabditis elegans, is a saprophytic species that has been emerging as a standard model organism since the early 1960s. This species is useful in numerous fields, including developmental biology, neurobiology, and ageing. A high-quality comprehensive molecular interaction network is needed to facilitate molecular mechanism studies in C. elegans.

Results

We present the predicted functional interactome of Caenorhabditis elegans (FIC), which integrates functional association data from 10 public databases to infer functional gene interactions on diverse functional perspectives. In this work, FIC includes 108,550 putative functional associations with balanced sensitivity and specificity, which are expected to cover 21.42% of all C. elegans protei

SUBMITTER: Chen PC 

PROVIDER: S-EPMC7574172 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature