Comparative efficacy of glucocorticoid receptor agonists on Th2 cell function and attenuation by progesterone.

ABSTRACT:

Background

Corticosteroids (CS)s suppress cytokine production and induce apoptosis of inflammatory cells. Prednisone and dexamethasone are oral CSs prescribed for treating asthma exacerbations. While prednisone is more commonly prescribed, dexamethasone is long acting and a more potent glucocorticoid receptor (GR) agonist. It can be administered as a one or two dose regime, unlike the five to seven days required for prednisone, a feature that increases compliance. We compared the relative ability of these two oral CSs to suppress type 2 inflammation. Since progesterone has affinity for the GR and women are more likely to relapse following an asthma exacerbation, we assessed its influence on CS action.

Results

Dexamethasone suppressed the level of IL-5 and IL-13 mRNA within T

SUBMITTER: Luchak A 

PROVIDER: S-EPMC7574173 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature