The combined antibacterial effects of sodium new houttuyfonate and berberine chloride against growing and persistent methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.

ABSTRACT:

Background

Infections caused by drug-resistant Staphylococcus aureus, especially vancomycin-intermediate Staphylococcus aureus (VISA), leave clinicians with limited therapeutic options for treatment. Persister cells is a leading cause of recalcitrant infection and antibiotic treatment failure, and there is no drug in clinical use that specifically targets persister cells currently. Here, we report a promising combination therapy of sodium new houttuyfonate (SNH) and berberine chloride (BBR) which is able to eradicate both growing and persistent drug-resistant Staphylococcus aureus.

Results

The susceptibility test showed SNH exhibited anti-MRSA activity with MIC₉₀ at 64 μg/mL, while BBR showed weak anti-MRSA activity with MIC₉₀ at 512 μg/mL. MICs of BBR

SUBMITTER: Li X 

PROVIDER: S-EPMC7574187 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature