Ontology highlight
ABSTRACT:
SUBMITTER: Shahin Varnoosfaderani F
PROVIDER: S-EPMC7574388 | biostudies-literature | 2020 Jun - Jul
REPOSITORIES: biostudies-literature
Shahin Varnoosfaderani Farzaneh F Palau Anna A Dong Wenbo W Persson Jenna J Durand-Dubief Mickaël M Svensson J Peter JP Lennartsson Andreas A
Epigenetics 20200110 6-7
The transcriptional program that dictates haematopoietic cell fate and differentiation requires an epigenetic regulatory and memory function, provided by a network of epigenetic factors that regulate DNA methylation, post-translational histone modifications and chromatin structure. Disturbed epigenetic regulation causes perturbations in the blood cell differentiation program that results in various types of haematopoietic disorders. Thus, accurate epigenetic regulation is essential for functiona ...[more]