Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women.

ABSTRACT:

Background

Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopausal women due to their decreased levels of estrogen. Preclinical studies with animals demonstrated that loss of estrogen had a negative effect on bone healing and that increasing the estrogen level led to a better bone healing. We asked whether increasing the estrogen level in menopausal patients has a beneficial effect on bone mineral density (BMD) during callus formation after a bone fracture.

Methods

To investigate whether estrogen has a beneficial effect on callus BMD of postmenopausal patients, we performed a prospective double-blinded randomized study with 76 pati

SUBMITTER: Jackle K 

PROVIDER: S-EPMC7574467 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature