Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic?

ABSTRACT:

Background

Infection by nematodes is a problem for human health, livestock, and agriculture, as it causes deficits in host health, increases production costs, and incurs a reduced food supply. The control of these parasites is usually done using anthelmintics, which, in most cases, have not been fully effective. Therefore, the search for new molecules with anthelmintic potential is necessary.

Methods

In the present study, we isolated and characterized molecules from the nematophagous fungus Pochonia chlamydosporia and tested these compounds on three nematodes: Caenorhabditis elegans; Ancylostoma ceylanicum; and Ascaris suum.

Results

The ethyl acetate extract showed nematicidal activity on the nematode model C. elegans. We identified the major substance present in two

SUBMITTER: Ferreira SR 

PROVIDER: S-EPMC7574484 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature