Gene Expression Profiling in Uveal Melanoma: Five-Year Prospective Outcomes and Meta-Analysis.

ABSTRACT:

Introduction

The prognostic 15-gene expression profile (15-GEP) test for uveal melanoma (UM) predicts metastatic risk based on primary tumor biology. Here we report outcomes from a prospective registry of 15-GEP-tested patients, and a meta-analysis with published cohorts.

Objectives

Management and 5-year clinical outcomes following 15-GEP testing were evaluated.

Methods

Eighty-nine patients with 15-GEP results were prospectively enrolled at four centers. Physician-recommended management plans were collected, and clinical outcomes tracked every 6 months.

Results

Eighty percent of Class 1 (low-risk) patients underwent low-intensity management; all Class 2 (high-risk) patients underwent high-intensity management (p < 0.0001). Median follow-up for event-free

SUBMITTER: Aaberg TM 

PROVIDER: S-EPMC7574618 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature