Allelic distribution of ABO gene in Chinese centenarians.

ABSTRACT:

Objective

Human ABO blood groups are determined by the alleles A, B, and O (O01 and O02) of the ABO gene and have been linked to the risks for cardiovascular diseases and cancers that affect lifespan.We examined the genetic associations of the ABO gene and blood groups with longevity.

Methods

We inspected the frequencies of the A, B, O, and O02 alleles in a large Chinese centenarian population (n = 2201) and in middle-aged controls (n = 2330). The single nucleotide polymorphisms were selected as allele A (rs507666), B (rs8176743, rs8176746, and rs8176749), O (rs687289), and O02 (rs688976, rs549446, and rs512770).

Results

Supported by allelic and genotypic associati

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7574633 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature