Spatial clusters of cancer incidence: analyzing 1940 census data linked to 1966-2017 cancer records.

ABSTRACT:

Purpose

A life course perspective to cancer incidence is important for understanding effects of the environment during early life on later cancer risk. We assessed spatial clusters of cancer incidence based on early life location defined as 1940 US Census Enumeration District (ED).

Methods

A cohort of 260,585 individuals aged 0-40 years in 1940 was selected. Individuals were followed from 1940 to cancer diagnosis, death, or last residence in Utah. We geocoded ED centroids in Utah for the 1940 Census. Spatial scan statistics with purely spatial elliptic scanning window were used to identify spatial clusters of EDs with excess cancer rates across 26 cancer types, assuming a discrete Poisson model.

Results

Cancer was diagnosed in 66,904 (25.67%) individuals during follow

SUBMITTER: Leiser CL 

PROVIDER: S-EPMC7574665 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature