Mechanical force modulates periodontal ligament stem cell characteristics during bone remodelling via TRPV4.

ABSTRACT:

Objectives

Mechanical force plays an important role in modulating stem cell fate and behaviours. However, how periodontal ligament stem cells (PDLSCs) perceive mechanical stimulus and transfer it into biological signals, and thereby promote alveolar bone remodelling, is unclear.

Materials and methods

An animal model of force-induced tooth movement and a compressive force in vitro was used. After force application, tooth movement distance, mesenchymal stem cell and osteoclast number, and proinflammatory cytokine expression were detected in periodontal tissues. Then, rat primary PDLSCs with or without force loading were isolated, and their stem cell characteristics including clonogenicity, proliferation, multipotent differentiation and immunoregulatory properties were evaluate

SUBMITTER: Jin SS 

PROVIDER: S-EPMC7574874 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature