Ontology highlight
ABSTRACT:
SUBMITTER: Balakrishnan I
PROVIDER: S-EPMC7574900 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cell reports 20201001 3
Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective treatment for this tumor. Using a combined RNAi and chemical screen targeting epigenomic regulators, we identify the polycomb repressive complex 1 (PRC1) component BMI1 as a critical factor for DIPG tumor maintenance in vivo. BMI1 chromatin occupancy is enriched at genes associate ...[more]