Risk scoring for time to end-stage knee osteoarthritis: data from the Osteoarthritis Initiative.

ABSTRACT:

Objective

This study constructs a risk score for patients' progression to end-stage knee osteoarthritis (OA) within 4 years.

Design

The Osteoarthritis Initiative (OAI) was a longitudinal study of the onset and progression of knee OA. Using a recent definition of end-stage knee OA, we implement interval-censored survival forests to select predictors of this endpoint. We fit an interval-censored Cox model for time to end-stage knee OA, using the selected predictors. The risk score is the Cox model's fitted linear combination of the nine selected baseline structural and symptomatic knee OA variables.

Results

We fit our models on a training set of 2,701 patients, and we evaluate on an independent test set of 1,436 patients. On the test sample, we observe a concordance ind

SUBMITTER: Dunn R 

PROVIDER: S-EPMC7575033 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature