Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior.

ABSTRACT: In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity. Both behavioral and learning-dependent reorganization of these connections has also been demonstrated by measuring spike transmission probabilities in pyramidal cell-interneuron spike cross-correlations that indicate monosynaptic connections. Here we investigated the activity-dependent modification of these connections during exploratory behavior in rats by optogenetically inhibiting pyramidal cell and interneuron subpopulations. Light application and associated firing alteration of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron connection weights as indicated by spike transmission changes. Sp

SUBMITTER: Gridchyn I 

PROVIDER: S-EPMC7575322 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature